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Typical Mitragyna speciosa Kratom doses can vary greatly, depending on such factors as potency of the Kratom, tolerance of the user and personal metabolism / response. It is rather clear that Kratom’s stimulant and sedative effects work in tandem. Yet with regular use, a tolerance develops to...

The concept of "drug tolerance”, refers to the gradual decrease of a subject’s reaction and sensitivity to a psychoactive substance or drug, implying that progressively larger doses are required to achieve the desired effect. Drug tolerance can involve both psychological drug tolerance as well...

The term “Opioids” is a blanket term used for any drug, including opiates, which are active by binding to the C.N.S. or gastrointestinal tract opioid receptors, thus having an action comparable to that of opiates. It is a broad class of narcotics whose activity comes from their receptor...

Mitragyna speciosa Kratom is illegal in many South-East Asian countries, such as Thailand, Malaysia, Myanmar (Burma) and Vietnam (though the specificities of the law is unclear). Kratom use is, however still quite common in these countries, especially in rural areas, even though these countries...

“Withdrawals” or “withdrawal symptoms”, also known as withdrawal/abstinence syndrome, refers to a series of characteristic signs and symptoms that appear when a drug is regularly used for a long time and then suddenly discontinued or decreased in dosage. Withdrawal is connected to forms of...

Selected bibliography on Mitragyna speciosa Kratom and Kratom alkaloids Amattayakul T., The kraton leaves. J. Department of Medical Sciences, Thailand, vol. 2: 2, 104-108, 1960. Atthakor P. "Role Seen For Traditional Herbal Stimulant": Bangkok Post November 27, 1999 Carbonin PU, Greco A...

A few Kratom users, those more sensitive than others, have had allergy-like reactions to Mitragyna speciosa Kratom, especially in higher doses, which causes them to feel a generalised body itching, similar to opioids. This unpleasant sensation is most likely due to histamine output, and can be...

As previously mentioned, despite Mitragyna speciosa Kratom’s relatively long history of human use, Kratom and Kratom use has rarely been studied extensively, even in countries where Kratom use is traditional. Such a country, Thailand, actually banned Kratom in 1943 (a ban which is now under...

Mitragyna speciosa Kratom use is legal in most parts of the world, and is not specifically tested for in drug-screens or drug tests. Yet Kratom users facing potential drug-tests, such as urine drug-screens, which are very common in the U.S.A. for instance- should be very careful with Kratom use...

As previously explained in the section “Pharmacology and mode of action of Mitragyna speciosa Kratom” as well as in the “Potential applications and modern uses of Mitragyna speciosa Kratom” section, Mitragyna speciosa Kratom actually has a strong potential as a substance to help with the...