Pharmacology and mode of action of Mitragyna speciosa Kratom

By Seirots · Dec 20, 2009 ·
  1. Seirots
    Mitragyna speciosa Kratom is most commonly classified as a “non-opioid narcotic”, yet this classification only partially reflects the effects of Kratom, which also has notable stimulant effects.

    Through its phyto-chemistry, pharmacology and psycho-physiological activity, Mitragyna speciosa Kratom shares some elements of the activity of various other substances, including opiates/opioids and yohimbine. Yet Mitragyna speciosa Kratom is really in a league of its own. Indeed, such a broad comparison is quite relative and dose related, Mitragyna speciosa Kratom and opiates being only comparable to a certain extent, and at doses high enough to produce such similarity of effects.

    Yet Mitragyna speciosa Kratom has been proven to have the ability to alleviate withdrawal in people dependent on opiates, a quality that is due to the μ and delta opioid receptor agonistic action of alkaloids mitragynine and 7-hydroxymitragynine.

    Mitragyna speciosa Kratom’s action is very much dose relative: at high doses, Kratom induces sedation and pain-relief / analgesia similar to weaker opiates such as codeine, cough suppression, and may cause constipation.

    Yet at lower doses, Mitragyna speciosa Kratom also has a stimulant activity, sometimes compared to that of Yohimbe, Ephedra or Coffee and immunostimulant activity sometimes compared to that of cat’s claw (Uncaria tomentosa)

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