Guidelines for safe and pleasant use of Kratom

Can Mitragyna speciosa Kratom be combined safely with other substances? In general, drug combination can be hazardous, problematic and risky, and one has to be careful of potentially negative or dangerous pharmaceutical interactions. One should proceed with caution, and with lower doses of both combined substances. Due to Mitragyna speciosa Kratom’s alkaloid specificities and mechanism of action, it is not recommended that Kratom, which has a stimulant nature in itself, be combined with...
Some combinations may actually potentiate the effects of Mitragyna speciosa Kratom, which is something to be aware of when experimenting with Kratom. Most of these Kratom potentiators are actually similar to those that work for opioids and opiates, since they act on similar receptors in similar ways. A basic potentiator is simply to take Mitragyna speciosa Kratom on an empty stomach, which can also help with nausea. Drinking grapefruit juice while taking Kratom (which works as a weak MAO...
Typical Mitragyna speciosa Kratom doses can vary greatly, depending on such factors as potency of the Kratom, tolerance of the user and personal metabolism / response. It is rather clear that Kratom’s stimulant and sedative effects work in tandem. Yet with regular use, a tolerance develops to the sedating opiate effect more quickly, which induces an increase of Kratom stimulation over time, on a regular rhythm of use, and this even with a lower Kratom dose, keeping track of one’s tolerance...
What is clear is that Mitragyna speciosa Kratom is not recommended for daily use. While such a practice is not nearly as problematic or dangerous as it would be with opiate or opioid use, it is clear that it is with regular use that most of Mitragyna speciosa Kratom’s side effects and health issues can occur. This is obviously not the best way, from a psycho-physiological or financial point of view, to enjoy Mitragyna speciosa Kratom. Also, as far as the nature of effects go, it is known...
Mitragyna speciosa Kratom has been used as a medicine and as a recreational psychoactive for a long time in South-East Asia, and is therefore known to be relatively safe. Yet it is important to note that Kratom’s action and eventual side effects are not yet fully understood or documented, and one should always proceed with caution. Western science is only beginning to pay attention to the effects and uses of Mitragyna speciosa Kratom, and what research already does exist contains some...
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