Can Mitragyna speciosa Kratom be combined safely with other substances?

In general, drug combination can be hazardous, problematic and risky, and one has to be careful of potentially negative or dangerous pharmaceutical interactions. One should proceed with caution, and with lower doses of both combined substances.

Due to Mitragyna speciosa Kratom’s alkaloid specificities and mechanism of action, it is not recommended that Kratom, which has a stimulant nature in itself, be combined with other stimulants such as yohimbine, cocaine, amphetamine-like drugs, or even large doses of caffeine.

The Mitragyna speciosa Kratom + stimulant combination can easily turn unpleasant, with increased risks of anxiety, agitation, increased heartbeat and palpitations, and there is a possibility of over-stimulation, increased blood pressure, and lowered seizure threshold.

Combining Mitragyna speciosa Kratom and psychedelics, as a combined experience rather than taking Kratom on the comedown, after a psychedelic trip, increases the risks of anxiety and agitation and general mental “freak-outs” due to Kratom’s stimulant nature, as with other psychedelic + stimulant combinations, (such as the psychedelic + amphetamines combo of the 1960’s) were famous for inducing. Using Kratom on the comedown of a psychedelic is less problematic.

Similarly, Mitragyna speciosa Kratom, as a depressant, should also not be combined with other C.N.S. depressants such as large amounts of alcohol, with benzodiazepines, opiates (other than possible use with red poppy tea—see below), sedative / hypnotics or any other drugs that depress the nervous system.

Such a combination, especially in higher doses, can have an additive or synergistic effect on the possibility that such combinations might cause over-sedation or even possible respiratory depression (not breathing).

Mitragyna speciosa Kratom should not be combined with Syrian rue, Banesteriopsis caapi, or any other M.A.O.i (Monoamine oxidases inhibitor) drug.

Serious, even fatal, reactions can occur if M.A.O. inhibitor drugs are combined with monoamine drugs. The combination of M.A.O. inhibitor drugs with Mitragyna speciosa Kratom, which contains monoamine alkaloids, has not yet been studied, so it is best to avoid this combination.

People taking S.S.R.I.’s (selective / specific serotonin reuptake inhibitors) are advised to use extra caution when taking Mitragyna speciosa Kratom, even if most people taking S.S.R.I.’s to this day have reported no problems with Kratom use.

Certain Kratom combinations have actually been reported by users to be pleasant and supposedly safe. Mitragyna speciosa Kratom can certainly be combined with ordinary tea without risk, notably for taste reasons. For some users, the intake of powdered ginger, (around 1.5 grams for instance) also greatly reduces the nausea. Sugar diminishes the bitterness, yet is not reported to change the effects or potency of Kratom.

Mitragyna speciosa Kratom has been successfully used in combination with a tea made from red poppy flowers (Papaver rhoeas), which itself has an extremely mild narcotic effect, and with a sedating / euphoriant tea made from ‘blue lotus’ (Nymphaea caerulea). Kratom has also been safely combined with SMALL quantities of alcohol, however large quantities of alcohol must be avoided, as this can severely increase nausea issues and be potentially dangerous through the increase in depressant effects.

Some people report that they like to smoke tobacco or cannabis while under the influence of Mitragyna speciosa Kratom. Cannabis and Kratom combinations are also often reported to have a pleasant synergistic effect.

But anyone smoking under the influence of Mitragyna speciosa Kratom should be very careful not to nod off and drop lit smoking materials.