Search results

Most of the alkaloids identified in Mitragyna speciosa Kratom are Yohimbe-type indoles and oxindoles. The most abundant alkaloids consist of three indoles and two oxindoles, and some indoles such as mitragynine, paynanthine and others are unique to the Mitragyna speciosa plant. Other indole...

This level has been compared to the effects of a mild opiate, such as codeine or a less complex poppy-tea. At this Kratom dosage, one is less sensitive to stress, physical or emotional pain, pretty much on par with weaker opiates such as codeine. Euphoric feelings are present, though not as...

The term “narcotic” is based on the Greek word “narcosis”, the term used by Hippocrates for the process of benumbing, benumbed or sedated state. A “narcotic” substance refers to agents that benumb or deaden, and by metaphorical extension those that cause loss of feelings, or sedation...

The term “sedative”, or “sedative-hypnotic” refers to a class of substances that depress the central nervous system (C.N.S.), which induces a state of calmness, relaxation, reduction of anxiety, sleepiness, and slowed breathing. Sedative-hypnotics may be also be referred to as tranquilizers...

The term “opiates” refers to the narcotic alkaloids extracted from opium poppy (Papaver somniferum ) pods and latex, and sometimes to their semi-synthetic counterparts. These alkaloid’s narcotic activity comes from their binding to the brain and gastro-intestinal opioid receptors ( codeine...

Opioid receptors are a group of G-protein coupled receptors that have opioids as ligands: a substance that is able to bind to and form a complex with a biomolecule, in order to serve a biological purpose. The opioid receptors are mainly found in the Central Nervous System (C.N.S.) and the...

At low doses, Mitragyna speciosa Kratom is stimulating, the more sedating effects being brought about by more opioid receptors binding as the dose range moves up. If this stimulant level of Kratom is very much related to the dose taken, it is also usually present to some extent at the beginning...

Kratom is the vernacular name given to a tree, Mitragyna speciosa indigenous to Southeast Asia (Thailand, Malaysia, Myanmar, Indonesia, P.N.G. and elsewhere) as well as to the psychoactive preparations made from the tree’s harvested leaves. While the name Kratom is now the most well known, the...

The Mitragyna speciosa Kratom tree grows naturally throughout Southeast Asia, yet little is known of its traditional consumption outside of Thailand, Malaysia, Myanmar/Burma, countries which have mentioned Kratom use in official documents and studies. This is mainly due to the fact that Kratom...

The dual nature of Mitragyna speciosa Kratom’s effects places it in a category of its own, and the common pharmacological classification of Kratom as a “non-opioid narcotic” does not accurately reflect this particularity. The main psychoactive effects of Kratom are indeed opioid like, somewhat...