Relatively unknown outside South-east Asia until recent times, the increased circulation of information and open medias such as the Internet, has allowed Mitragyna speciosa Kratom to be introduced to the dynamic community of users and researchers of psychoactive substances.

Mitragyna speciosa Kratom is now known and sold around the world for its pleasant and relaxing effects, mainly via online vendors.

Through its previously described action on the delta opioid receptors, similar to that of opiates, Kratom provides a calm and relaxing pleasure close to that of opiates, but is also a mild stimulant, with much less addiction potential an side effects.

A form of tolerance does settle, however, meaning that the user requires more Kratom to achieve the same effects, but is also kept in check by the balance between Kratom’s sedative and stimulant effects.

This is why it is recommended that users do not use Mitragyna speciosa Kratom more than twice a week, to keep such potential tolerance issues under control, and avoid habituation.

Cross-tolerance of Kratom with opiates has also been noted, implying that a user can build a tolerance for both Kratom and opiates through Mitragyna speciosa Kratom use only. This could pose a problem for pain medication prescription with opioid like action, as someone using Kratom regularly would need higher dosages.