Some combinations may actually potentiate the effects of Mitragyna speciosa Kratom, which is something to be aware of when experimenting with Kratom.

Most of these Kratom potentiators are actually similar to those that work for opioids and opiates, since they act on similar receptors in similar ways.

A basic potentiator is simply to take Mitragyna speciosa Kratom on an empty stomach, which can also help with nausea. Drinking grapefruit juice while taking Kratom (which works as a weak MAO Inhibitor) is also said to increase the Kratom’s potency.